Which command has cradle-to-grave responsibility of a weapon system?

The command that holds cradle-to-grave responsibility for a weapon system is the Air Force Materiel Command (AFMC). This encompasses the entire lifecycle of the weapon system, starting from the initial design and development phases through production, sustainment, and ultimately to the retirement and disposal of the system. The AFMC is tasked with ensuring that weapon systems are developed efficiently, maintained properly, and disposed of in accordance with regulations and best practices. This holistic approach ensures that the system effectiveness is maximized throughout its operational life, supporting mission readiness and efficiency.

Other commands mentioned may have specific roles related to operations, logistics, or support, but none possess the comprehensive oversight and management responsibilities associated with the complete lifecycle of weapon systems like AFMC does.